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Series GSE72249 Query DataSets for GSE72249
Status Public on Apr 08, 2016
Title Characterization of ER, GR, and FoxA1 binding patterns in breast cancer cells treated with either Dex or E2
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 is well-established as a pioneer factor for steroid receptor recruitment to chromatin. Here we show that ER and GR have the ability to alter the genomic response of FoxA1 to specific binding sites within the genome. These findings alter the classical understood mechanism of FoxA1 establishing a dynamic transcription factor that can be regulated by hormones.
 
Overall design We examined the ER and GR mediated affects on FoxA1 binding patterms
 
Contributor(s) Swinstead EE, Baek S, Hager GL
Citation(s) 27062924
Submission date Aug 20, 2015
Last update date May 15, 2019
Contact name Songjoon Baek
Organization name NCI / NIH
Department CCR
Lab LRBGE
Street address 41 Library Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (45)
GSM1858616 untreated rep#1 GR ChIP-seq GH913
GSM1858617 untreated rep#2 GR ChIP-seq GH921
GSM1858618 Dex rep#1 GR ChIP-seq GH1158
This SubSeries is part of SuperSeries:
GSE72252 DNaseI hypersensitivity assay and ER, GR, and FoxA1 binding patterns in breast cancer cells
Relations
BioProject PRJNA293471
SRA SRP062679

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE72249_RAW.tar 3.9 Gb (http)(custom) TAR (of BEDGRAPH)
GSE72249_hs_RC_Dex_FoxA1_T47D_RC_GH1071xGH1461_FDR0.csv.gz 1.2 Mb (ftp)(http) CSV
GSE72249_hs_RC_E2_FoxA1_T47D_RC_GH1072xGH1462_FDR0.csv.gz 1.2 Mb (ftp)(http) CSV
GSE72249_hs_RC_FoxA1_Dex_RC_GH918GH926_FDR0.0.csv.gz 1.0 Mb (ftp)(http) CSV
GSE72249_hs_RC_FoxA1_E2_RC_GH919GH927_FDR0.0.csv.gz 1.2 Mb (ftp)(http) CSV
GSE72249_hs_RC_MCF7_ER_E2_RC_GH622xGH630_FDR0.csv.gz 509.0 Kb (ftp)(http) CSV
GSE72249_hs_RC_MCF7_ER_unt_RC_GH620xGH628_FDR0.csv.gz 238.7 Kb (ftp)(http) CSV
GSE72249_hs_RC_MCF7_FoxA1_Unt_RC_GH917xGH925_FDR0.csv.gz 1.2 Mb (ftp)(http) CSV
GSE72249_hs_RC_MCF7_GR_Dex_RC_GH1158xGH1159_FDR0.csv.gz 525.7 Kb (ftp)(http) CSV
GSE72249_hs_RC_MCF7_GR_unt_RC_GH913xGH921_FDR0.csv.gz 26.7 Kb (ftp)(http) CSV
GSE72249_hs_RC_T47D_ER_E2_RC_GH985GH993_FDR0.0.csv.gz 530.8 Kb (ftp)(http) CSV
GSE72249_hs_RC_T47D_ER_Unt_RC_GH983GH991_FDR0.0.csv.gz 353.9 Kb (ftp)(http) CSV
GSE72249_hs_RC_T47D_GR_Dex_RC_GH944GH988_FDR0.0.csv.gz 64.0 Kb (ftp)(http) CSV
GSE72249_hs_RC_T47D_GR_Unt_RC_GH943GH987_FDR0.0.csv.gz 26.3 Kb (ftp)(http) CSV
GSE72249_hs_RC_Unt_FoxA1_T47D_RC_GH1070xGH1460_FDR0.csv.gz 1.5 Mb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_ER_E2_RC_GH1001GH1010_FDR0.0.csv.gz 970.7 Kb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_ER_Unt_RC_GH999GH1008_FDR0.0.csv.gz 613.5 Kb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_FoxA1_Dex_RC_GH1063xGH1067_FDR0.csv.gz 2.0 Mb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_FoxA1_E2_RC_GH1064xGH1068_FDR0.csv.gz 1.6 Mb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_FoxA1_unt_RC_GH1062xGH1066_FDR0.csv.gz 1.7 Mb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_GR_Dex_RC_GH996GH1005_FDR0.0.csv.gz 823.3 Kb (ftp)(http) CSV
GSE72249_hs_RC_ZR751_GR_Unt_RC_GH995GH1004_FDR0.0.csv.gz 224.6 Kb (ftp)(http) CSV
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Raw data are available in SRA
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Processed data are available on Series record

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