|
| Status |
Public on Jul 31, 2015 |
| Title |
High Dose Tamoxifen in the Mouse Gastric Epithelium |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. Tamoxifen injection (3 consecutive days, intraperitoneal, 5mg/20g mouse body weight) causes dramatic rearrangement of the gastric mucosa with loss of > 90% of PCs, a 6-fold increase in proliferation in stem/progenitor cells, and morphological changes in the ZCs in the bases of gastric-units.
|
| |
|
| Overall design |
Time course of injection of high-dose tamoxifen. 3 mice were pooled for each condition.
|
| |
|
| Contributor(s) |
Huh WJ, Mills JC, Moore BD |
| Citation(s) |
26514774 |
| |
| Submission date |
Jul 30, 2015 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Jason Mills |
| E-mail(s) |
jmills@wustl.edu
|
| Phone |
3143624258
|
| Organization name |
Washington University in St. Louis
|
| Street address |
Department of Medicine - GI
|
| City |
St. Louis |
| State/province |
Mo |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA291541 |
Less...
More...