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Series GSE71340 Query DataSets for GSE71340
Status Public on Jul 27, 2016
Title Neoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy.
 
Overall design tRNA was isolated from 35 omental tissue samples of HGSOC metastases either pre or post NACT treatment. RNASeq was performed on poly-A selected mRNA fragments, 100 b.p paired end, and strand specific, on average 40 million reads per sample.
 
Contributor(s) Pearce OM, Boehm S, Chakravarty P, Balkwill F
Citation(s) 27306793
Submission date Jul 24, 2015
Last update date May 15, 2019
Contact name Oliver Pearce
E-mail o.pearce@qmul.ac.uk
Organization name Queen Mary University of London
Department Barts Cancer Institute
Lab Cancer and Inflammation
Street address Charterhouse Square
City London
ZIP/Postal code EC1M 6BQ
Country United Kingdom
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (35)
GSM1832768 PRE-NACT X82
GSM1832769 PRE-NACT X124
GSM1832770 PRE-NACT X136
Relations
BioProject PRJNA290924
SRA SRP061571

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71340_refseq_count_data.txt.gz 1.2 Mb (ftp)(http) TXT
Raw data are available in SRA
Processed data is available on Series record

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