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Series GSE71340 Query DataSets for GSE71340
Status Public on Jul 27, 2016
Title Neoadjuvant chemotherapy modulates T cell responses in high-grade serous ovarian cancer metastases
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our data suggest that neoadjuvant chemotherapy enhances anti-cancer responses of T cells in peritoneal metastases of patients with high-grade serous ovarian cancer but does not decrease levels of immune checkpoint molecules, providing a rationale for sequential chemo-immunotherapy.
Overall design tRNA was isolated from 35 omental tissue samples of HGSOC metastases either pre or post NACT treatment. RNASeq was performed on poly-A selected mRNA fragments, 100 b.p paired end, and strand specific, on average 40 million reads per sample.
Contributor(s) Pearce OM, Boehm S, Chakravarty P, Balkwill F
Citation(s) 27306793, 29196464, 31940494
Submission date Jul 24, 2015
Last update date Jan 27, 2020
Contact name Oliver Pearce
Organization name Queen Mary University of London
Department Barts Cancer Institute
Lab Cancer and Inflammation
Street address Charterhouse Square
City London
ZIP/Postal code EC1M 6BQ
Country United Kingdom
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (35)
GSM1832768 PRE-NACT X82
GSM1832769 PRE-NACT X124
GSM1832770 PRE-NACT X136
BioProject PRJNA290924
SRA SRP061571

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71340_refseq_count_data.txt.gz 1.2 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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