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Series GSE71276 Query DataSets for GSE71276
Status Public on Oct 01, 2015
Title LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary HOTAIR is up-regulated in tamoxifen-resistant breast cancer tissues compared to their primary counterparts. Mechanistically, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the blockade of ER signaling, either by hormone deprivation or tamoxifen treatment.
Overall design ChIP-Seq examination of ER binding sites in MCF7 cells.
Contributor(s) Yu J, Xue X
Citation(s) 26364613
Submission date Jul 23, 2015
Last update date May 15, 2019
Contact name Jindan Yu
Organization name Northwestern University
Department Division of Hematology/Oncology
Lab Jindan Yu's lab
Street address 303 E. Superior St., Lurie 5-117
City Chicago
State/province IL
ZIP/Postal code 60611
Country USA
Platforms (1)
GPL15456 Illumina HiScanSQ (Homo sapiens)
Samples (4)
GSM1831736 MCF7 ER ChIP-seq CTRL
GSM1831737 MCF7 ER ChIP-seq HOTAIR
GSM1831738 MCF7 ER ChIP-seq E2 CTRL
This SubSeries is part of SuperSeries:
GSE71298 LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
BioProject PRJNA290780
SRA SRP061461

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71276_RAW.tar 229.4 Mb (http)(custom) TAR (of BEDGRAPH)
GSE71276_m186vsm187_m186_peak.txt.gz 56.9 Kb (ftp)(http) TXT
GSE71276_m186vsm187_m186_peak_m187_peak.txt.gz 58.4 Kb (ftp)(http) TXT
GSE71276_m186vsm187_m187_peak.txt.gz 99.7 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m188_peak.txt.gz 132.2 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m188_peak_m189_peak.txt.gz 443.8 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m189_peak.txt.gz 179.3 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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