NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE71276 Query DataSets for GSE71276
Status Public on Oct 01, 2015
Title LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary HOTAIR is up-regulated in tamoxifen-resistant breast cancer tissues compared to their primary counterparts. Mechanistically, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the blockade of ER signaling, either by hormone deprivation or tamoxifen treatment.
 
Overall design ChIP-Seq examination of ER binding sites in MCF7 cells.
 
Contributor(s) Yu J, Xue X
Citation(s) 26364613
Submission date Jul 23, 2015
Last update date May 15, 2019
Contact name Jindan Yu
E-mail(s) jindan-yu@northwestern.edu
Organization name Northwestern University
Department Division of Hematology/Oncology
Lab Jindan Yu's lab
Street address 303 E. Superior St., Lurie 5-117
City Chicago
State/province IL
ZIP/Postal code 60611
Country USA
 
Platforms (1)
GPL15456 Illumina HiScanSQ (Homo sapiens)
Samples (4)
GSM1831736 MCF7 ER ChIP-seq CTRL
GSM1831737 MCF7 ER ChIP-seq HOTAIR
GSM1831738 MCF7 ER ChIP-seq E2 CTRL
This SubSeries is part of SuperSeries:
GSE71298 LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
Relations
BioProject PRJNA290780
SRA SRP061461

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71276_RAW.tar 229.4 Mb (http)(custom) TAR (of BEDGRAPH)
GSE71276_m186vsm187_m186_peak.txt.gz 56.9 Kb (ftp)(http) TXT
GSE71276_m186vsm187_m186_peak_m187_peak.txt.gz 58.4 Kb (ftp)(http) TXT
GSE71276_m186vsm187_m187_peak.txt.gz 99.7 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m188_peak.txt.gz 132.2 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m188_peak_m189_peak.txt.gz 443.8 Kb (ftp)(http) TXT
GSE71276_m188vsm189_m189_peak.txt.gz 179.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap