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| Status |
Public on Dec 06, 2016 |
| Title |
Creb overexpression induces leukemia in zebrafish by blocking myeloid differentiation process |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
|
| Summary |
To examine the role of CREB overexpression in hematopoiesis, we created a model of leukemia in zebrafish by overexpressing the human CREB in the myeloid hematopoietic lineage. Whole transcriptome analysis of kidney-marrow revealed 171 genes differently expressed between CREB- and control-zebrafish (five per group). Interestingly, the integration of this signature with human deposited data revealed that this tumor resembled a human AML at transcriptome level.
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| |
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| Overall design |
Gene expression analysis of kidney marrow from CREB-zebrafish and zebrafish controls (five animals per group).
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| |
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| Contributor(s) |
Borga C, Tregnago C, Pigazzi M, Basso G |
| Citation(s) |
27118402 |
| Submission date |
Jul 23, 2015 |
| Last update date |
Jan 25, 2018 |
| Contact name |
Chiara Borga |
| E-mail(s) |
chiaraborga@gmail.com
|
| Organization name |
University of Padua
|
| Street address |
Corso Stati Uniti,4
|
| City |
Padova |
| ZIP/Postal code |
35127 |
| Country |
Italy |
| |
|
| Platforms (1) |
| GPL1319 |
[Zebrafish] Affymetrix Zebrafish Genome Array |
|
| Samples (10)
|
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| Relations |
| BioProject |
PRJNA290733 |
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