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Series GSE70863 Query DataSets for GSE70863
Status Public on Sep 14, 2015
Title Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells (RNA-seq)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Our study reports the first genome-wide atlas of functional nodes that mediate proviral silencing in ESCs. It provides evidences for the comprehensive, interconnected and multi-layered genetic/epigenetic machineries by which ESCs maintain the repressive state of provirus and ERVs.
 
Overall design RNA-seq analysis to determine the regulated endogenous retroviruses by Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/ Ube2i/Sae1/Uba2/Senp6) and chromatin modifiers (Trim28/Eset/Atf7ip)
 
Contributor(s) Yang BX, EL Farran CA, Guo HC, Yu T, Fang HT, Loh Y
Citation(s) 26365490
Submission date Jul 13, 2015
Last update date May 15, 2019
Contact name Chadi El Farran
Organization name Institute of Molecular and Cell Biology
Lab Epigenetics and Cell Fates Laboratory
Street address 61 Biopolis Drive
City Singapore
ZIP/Postal code 138673
Country Singapore
 
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (23)
GSM1820674 Control-for-Group 1-Rep1
GSM1820675 Control-for-Group 1-Rep2
GSM1820676 Group1_shSae1_Rep1
This SubSeries is part of SuperSeries:
GSE70865 Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells
Relations
BioProject PRJNA289719
SRA SRP060878

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70863_Group1_Genes.txt.gz 1.9 Mb (ftp)(http) TXT
GSE70863_Group1_LTR.txt.gz 14.5 Kb (ftp)(http) TXT
GSE70863_Group2_Genes.txt.gz 1.9 Mb (ftp)(http) TXT
GSE70863_Group2_LTR.txt.gz 13.2 Kb (ftp)(http) TXT
GSE70863_Group3_Genes.txt.gz 1.6 Mb (ftp)(http) TXT
GSE70863_Group3_LTR.txt.gz 7.5 Kb (ftp)(http) TXT
GSE70863_Group4_Genes.txt.gz 1.6 Mb (ftp)(http) TXT
GSE70863_Group4_LTR.txt.gz 7.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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