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Status |
Public on Sep 14, 2015 |
Title |
Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells (RNA-seq) |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Our study reports the first genome-wide atlas of functional nodes that mediate proviral silencing in ESCs. It provides evidences for the comprehensive, interconnected and multi-layered genetic/epigenetic machineries by which ESCs maintain the repressive state of provirus and ERVs.
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Overall design |
RNA-seq analysis to determine the regulated endogenous retroviruses by Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/ Ube2i/Sae1/Uba2/Senp6) and chromatin modifiers (Trim28/Eset/Atf7ip)
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Contributor(s) |
Yang BX, EL Farran CA, Guo HC, Yu T, Fang HT, Loh Y |
Citation(s) |
26365490 |
Submission date |
Jul 13, 2015 |
Last update date |
May 15, 2019 |
Contact name |
Chadi El Farran |
Organization name |
Institute of Molecular and Cell Biology
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Lab |
Epigenetics and Cell Fates Laboratory
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Street address |
61 Biopolis Drive
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City |
Singapore |
ZIP/Postal code |
138673 |
Country |
Singapore |
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Platforms (1) |
GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
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Samples (23)
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This SubSeries is part of SuperSeries: |
GSE70865 |
Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells |
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Relations |
BioProject |
PRJNA289719 |
SRA |
SRP060878 |