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Series GSE70418 Query DataSets for GSE70418
Status Public on Oct 06, 2015
Title A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged
Organism Mus musculus
Experiment type Expression profiling by array
Summary The polytrauma (PT) murine model has unique transcriptomic responses 2 hrs, 1 day and 3 days after injury. We determined with this clinically relevant model that the increased morbidity in the elderly is secondary to a failure of bone marrow progenitors, blood neutrophils, and bronchoalveolar lavage cells to initiate and complete an 'emergency myelopoietic' response, engendering myeloid cells that fail to clear secondary infection. In addition, the elderly appear unable to effectively resolve their inflammatory response to severe injury.
Overall design We used mouse microarrays to detail the molecular profile of the events that occur following injury in mice models.
Contributor(s) Nacionales DC, Szpila B, Ungaro R, Lopez MC, Zhang J, Gentile LF, Cuenca AL, Vanzant E, Mathias B, Jyot J, Westerveld D, Bihorac A, Joseph A, Mohr A, Duckworth LV, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Brakenridge S, Efron PA
Citation(s) 26246141
Submission date Jun 30, 2015
Last update date Feb 11, 2019
Contact name M Cecilia Lopez
Phone 352 273-8133
Organization name University of Florida
Department Molecular Genetics and Microbiology
Lab Microarray lab 103
Street address 1376 Mowry Road
City Gainesville
State/province FL
ZIP/Postal code 32610-3610
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (69)
GSM1255366 Control r1
GSM1255367 Control r2
GSM1255368 Control r3
BioProject PRJNA288591

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70418_RAW.tar 231.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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