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| Status |
Public on Mar 01, 2004 |
| Title |
HMF3A_RNAi |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
HMF3A cells, created from adult human mammary fibroblasts by immortalisation with a thermolabile SV40 large T antigen and the catalytic sub-unit of human telomerase, undergo co-ordinated induction of cellular senescence upon inactivation of T antigen.
The pSUPER-retro vector system (Brummelkamp, 2002) was used to selectively target genes for mRNA degradation in an attempt to determine if they had a role, in the changes to the transcriptome upon LT inactivation. The genes chosen for targeting were BTG2, NR4A3, DUSP1, PHLDA1 and STACb.
Keywords = LT antigen
Keywords = senescence
Keywords = fibroblast
Keywords = BTG2
Keywords = DUSP1
Keywords = MKP-1
Keywords = NR4A3
Keywords = STAC
Keywords = PHLDA1
Keywords = RNAi
Keywords: other
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| Contributor(s) |
Hardy K, Mansfield L, Mackay A, Benvenuti S, O'Hare M, Jat P |
| Citation(s) |
15574883 |
| Submission date |
Sep 30, 2003 |
| Last update date |
Mar 02, 2012 |
| Contact name |
Kristine Hardy |
| E-mail(s) |
kristine.hardy@anu.edu.au
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| Organization name |
University of Canberra
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| Lab |
Cytokine Gene Expression
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| Street address |
University of Canberra
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| City |
Bruce |
| State/province |
ACT |
| ZIP/Postal code |
0200 |
| Country |
Australia |
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| Platforms (1) |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA87643 |
| Supplementary data files not provided |
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