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Series GSE68946 Query DataSets for GSE68946
Status Public on May 16, 2015
Title Mouse lung tissue transcriptome response to a wild type infectious clone of H7N9 Influenza virus and mutant H7N9 viruses [microRNA]
Organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse lung infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus).
 
Overall design Groups of 22-week-old C57BL/6 mice were infected with the H7N9 Influenza WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Infections were done at 10^4 PFU or time-matched mock infected. Time points were 1, 2, 4 and 7 d.p.i. There were 5 animals/dose/time point. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.
 
Contributor(s) Stratton K, Waters KM, Eisfeld AJ, Kawaoka Y
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Submission date May 15, 2015
Last update date Aug 31, 2016
Contact name Natalie Heller
E-mail natalie.heller@pnnl.gov
Organization name PNNL
Street address 902 Battelle Blvd.
City Richland
ZIP/Postal code 99354
Country USA
 
Platforms (1)
GPL19970 Agilent-046065 Mouse_miRNA_V19.0_Microarray [Probe Name version]
Samples (23)
GSM1687525 IM102_Lung_Mock_2d_miRNA_1
GSM1687526 IM102_Lung_Mock_2d_miRNA_2
GSM1687527 IM102_Lung_Mock_2d_miRNA_3
This SubSeries is part of SuperSeries:
GSE65575 Modeling Host Responses to Understand Severe Human Virus Infections
Relations
BioProject PRJNA284143

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68946_Normalized_data_with_annotation.txt.gz 430.4 Kb (ftp)(http) TXT
GSE68946_RAW.tar 65.5 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data is available on Series record

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