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| Status |
Public on Aug 01, 2015 |
| Title |
Exon expression for NCI Sarcoma cell line panel |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Characterization of 68 cell lines derived from human sarcoma and 5 normal counterpart cells, including drug sensitivity testing, gene expression profiling and microRNA expression profiling have been completed. Data and tools for searching these data will be made publicly available through the NCI Developmental Therapeutics Program. The raw data (.cel files ) are provided through the GEO website. Sarcoma represents a variety of cancers at arise from cells of mesenchymal origin and have seen limited treatment advances in the last decade. Drug sensitivity data coupled with the transcription and microRNA profiles of a cohort of sarcoma cell lines may help define novel treatment paradigms.
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| Overall design |
For each cell line, exon expression was measured using Genechip Human Exon 1.0 ST arrays from Affymetrix, interrogating > 1 million exon clusters, to provide comprehensive coverage of the entire genome at the exon and gene expression level.
Please note that there are 2 replicates included in the study:
Arrays 1 (GSM1676295) and 49 (GSM1676338) are replicates of the A-204 cell line
Arrays 9 (GSM1676369) and 50 (GSM1676340) are replicates of the ES-4 cell line
The sample titles represent are the cell line names (e.g. A-204, EW8 etc.).
The drug screening data and details are provided in the 'NCI-Sarcoma-median-log10-IC50.csv' and 'drug_screening_readme.txt', respectively.
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| Contributor(s) |
Monks A, Polley E, Teicher B |
| Citation(s) |
26351324 |
| Submission date |
May 05, 2015 |
| Last update date |
Sep 11, 2015 |
| Contact name |
Eric C Polley |
| E-mail(s) |
eric.polley@nih.gov
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| Organization name |
National Cancer Institute
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| Department |
Biometric Research Branch
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| Street address |
9609 Medical Center Drive, Rm 5W118
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| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
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| Platforms (1) |
| GPL11028 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [HuEx-1_0-st-v2,coreR3,A20071112,EP.cdf] |
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| Samples (75)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA285893 |
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