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Series GSE68162 Query DataSets for GSE68162
Status Public on Apr 23, 2015
Title Expression data from MAP3K11/GDF15 axis is a critical driver of cancer cachexia
Organism Mus musculus
Experiment type Expression profiling by array
Summary MAP3K11 overexpression in tumors leads to weight loss in the host
Overall design We assessed the ability of potential tumor maintenance genes to drive tumor growth in vivo using a directed complementation (DC) approach. This assay involves testing the ability of an introduced gene to maintain tumor growth when expression of an inducible driving oncogene is turned off. In this case, we tested the ability of MAP3K7/TAK1 or MAP3K11/MLK3 to form tumors in vivo in a genetically engineered model originally driven by a doxycycline-inducible HER2(V659E) oncogene. In this system, the expression and activity of HER2 was suppressed by doxycycline withdrawal and followed by the introduction of one of 13 genes (ErbB3, FAK1, FGFR2aIIIb, FGFR2aIIIc, FGFR3, HER2, MAP3K11, PIP5K1B, RONd160, RON+MSP, RSK2, MAP3K7, TNK2)
Contributor(s) Nicoletti R, Lerner L
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Submission date Apr 22, 2015
Last update date Feb 11, 2019
Contact name Lorena Lerner
Organization name AVEO Oncology
Street address 650 E. Kendall Street
City Cambridge
State/province MA
ZIP/Postal code 02142
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (76)
GSM1664772 DC ErbB3 tumor at T1, biological replicate 1
GSM1664773 DC ErbB3 tumor at T1, biological replicate 2
GSM1664774 DC ErbB3 tumor at T2, biological replicate 1
BioProject PRJNA281929

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE68162_RAW.tar 261.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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