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| Status |
Public on Feb 20, 2017 |
| Title |
Inflammatory cytokines activate unliganded estrogen receptor and alter the sensitivity of breast cancer cells to tamoxifen |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing Expression profiling by high throughput sequencing
|
| Summary |
Genome-wide analyses of the transcriptomes and transcription factor recruitment in estrogen receptor breast cancer cells in response to estradiol, IL1b, or TNFa treatments. Also, the role of inflammatory cytokines on affecting tamoxifen sensitivity is analyzed on a genome-wide scale.
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| Overall design |
Transcription factor binding (ERa, p65) and transcriptome analyses were performed in estradiol- and pro-inflammatory cytokine-treated MCF7 cells.
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| Contributor(s) |
Glass CK |
| Citation(s) |
28306507 |
| |
| Submission date |
Mar 25, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Joshua D Stender |
| Organization name |
University of California at San Diego
|
| Street address |
9500 Gillman
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (56)
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| Relations |
| BioProject |
PRJNA279424 |
| SRA |
SRP056552 |