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| Status |
Public on May 03, 2017 |
| Title |
Genome-wide detection of STAT3 binding sites in human Th17 cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
STAT3 is a major transcription factor driving the polarization of Th17 cells in response to IL-6, TGF-β and IL1-β. STAT3 is phosphorylated and forms a homodimer and translocates into the nucleus. There STAT3 binds to specific DNA sequences, regulating the transcription of its target genes. Here we have analyzed on a genome wide level the STAT3 binding sites, after 0.5h and 4h of IL-6, TGF-β and IL1-β induction, in naive human CD4+ T cells.
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| Overall design |
Altogether 2 samples from 1 biological replicate were analyzed.
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| Contributor(s) |
Tripathi S, Lahesmaa R |
| Citation(s) |
28564606 |
| |
| Submission date |
Mar 23, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Tarmo Äijö |
| Organization name |
Flatiron Institute
|
| Department |
Center for Computational Biology
|
| Street address |
162 5th Avenue
|
| City |
New York |
| ZIP/Postal code |
10010 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL9115 |
Illumina Genome Analyzer II (Homo sapiens) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA279200 |
| SRA |
SRP056442 |
