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Series GSE66878 Query DataSets for GSE66878
Status Public on Mar 13, 2016
Title Induced of RBM24 expression effect on nasopharyngeal carcinoma cells
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary RNA-binding proteins (RBPs) are key components in the determination of miRNA function, as they control different stages of miRNA biogenesis and their localization, degradation and activity. To further investigate the underlying mechanisms of RBM24 in nasopharyngeal carcinoma (NPC) carcinogenesis, we compared the miRNA expression profiles in RBM24 induced and control cells by using human miRNA microarray. Microarray analysis identified 11 commonly upregulated and 12 commonly downregulated miRNAs in RBM24 induced cells. Among the 23 miRNAs, miR-25 ranked highest of all the commonly upregulated genes sorted in ascending order according to fold change values. RBM24 expression was controlled by tetracycline-off system in NPC cells.
Overall design microRNA profiling of RBM24 expression induced cells vs. repressed cells: The expression of RBM24 in HONE-1, 5-8F, and CNE-2 cells was induced by removing doxycycline or repressed by adding doxycycline.
Contributor(s) Hua W, Zhang M, Zeng M
Citation(s) 27584791
Submission date Mar 13, 2015
Last update date Dec 28, 2016
Contact name Mei-Yin Zhang
Organization name Sun Yat-sen University Cancer Center
Department State Key Laboratory of Oncology in South China
Street address 651 Dongfeng East Road
City Guangzhou
State/province Guangdong
ZIP/Postal code 510060
Country China
Platforms (1)
GPL19888 State Key Laboratory Human microRNA array 1858
Samples (6)
GSM1633695 HONE-1-R1-ON
GSM1633696 HONE-1-R1-OFF
GSM1633697 CNE-2-R1-ON
BioProject PRJNA278156

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Supplementary file Size Download File type/resource
GSE66878_RAW.tar 940.0 Kb (http)(custom) TAR (of GPR)
Raw data provided as supplementary file
Processed data included within Sample table

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