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| Status |
Public on Apr 28, 2016 |
| Title |
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Mutant p53 proteins, resulting from the missense mutations of the TP53 tumor suppressor gene, possess gain-of-function activities and are among the most robust oncoproteins in human tumors. They are potentially important therapeutic targets. To complement our mutant p53 transcriptomic studies we have performed ChIP-seq analysis in MDA-MB-231 (R280K) using the mouse anti-p53 DO1 antibody or control mouse IgG versus the input material.
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| Overall design |
ChIP-seq analysis was performed in MDA-MB-231 (R280K) using the mouse anti-p53 DO1 antibody (Santa Cruz Biotech.) and MDA-MB-231 (R280K) with mouse unspecific IgG antibody (Santa Cruz Biotech.) as negative control.
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| Contributor(s) |
Morelli MJ, Walerych D |
| Citation(s) |
27347849 |
| |
| Submission date |
Mar 04, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Marco J. Morelli |
| E-mail(s) |
Marco.Morelli@iit.it
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| Organization name |
Istituto Italiano di Tecnologia
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| Department |
Center for Genomic Science of IIT@SEMM
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| Street address |
via Adamello 16
|
| City |
Milan |
| ZIP/Postal code |
20139 |
| Country |
Italy |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA277233 |
| SRA |
SRP055837 |
