|
| Status |
Public on Dec 31, 2015 |
| Title |
Essential Role of Sirt2 in Type I Interferon Signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We provide evidence for the essential role of Sirt2 in IFN mediated signaling. Our studies demonstrate that SIRT2 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
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| |
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| Overall design |
Total RNA was isolated from untreated and IFNβ-treated Sirt2+/+ and Sirt2-/- mouse embryonic fibroblasts (MEFs). Cells were treated for 4hours with or without mouse IFNβ (2500 IU/ml).
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| |
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| Contributor(s) |
Mehrotra S, Lisowski P, Platanias LC |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 18, 2015 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Pawel Lisowski |
| E-mail(s) |
pawel.lisowski@mdc-berlin.de
|
| Phone |
+493094061370
|
| Organization name |
Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association
|
| Street address |
Hannoversche Str. 28
|
| City |
Berlin |
| ZIP/Postal code |
10115 |
| Country |
Germany |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (12)
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| Relations |
| BioProject |
PRJNA275736 |
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