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Series GSE65997 Query DataSets for GSE65997
Status Public on Feb 18, 2015
Title The Nicotinic alpha6 Subunit Gene Determines Variability in Chronic Pain Sensitivity and Nicotine Anti- allodynia via Cross-inhibition of P2X2/3 Receptors.
Organism Mus musculus
Experiment type Expression profiling by array
Summary We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia a prominent symptom of chronic pain.
Expression genetics identifies a role for the Chrna6 (alpha 6-nicotinic receptor) gene in pain in mice and humans.
Overall design Dorsal root ganglion tissue across multiple inbred mouse strains, both male and female
Contributor(s) Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin J, Dai F, Zhang J, Marcovitz J, Tuttle AH, Slepian PM, Clarke S, Drenan RM, Janes J, Al Sharari S, Segall SK, Aasvang EK, Lai W, Bittner R, Richards CI, Slade GD, Kehlet H, Walker J, Maskos U, Changeux J, Devor M, Maixner W, Diatchenko L, Belfer I, Dougherty DA, Su AI, Lummis SR, Damaj MI, Lester HA, Patapoutian A, Mogil JS
Citation(s) 25972004
Submission date Feb 17, 2015
Last update date Feb 11, 2019
Contact name John R Walker
Phone 858-812-1636
Organization name Genomics Institute of the Novartis Research Foundation
Lab Genetics Core
Street address 10675 John Jay Hopkins
City San Diego
State/province CA
ZIP/Postal code 92121
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (50)
GSM1612366 male,AKR/J,strain, dorsal root ganglion tissue
GSM1612367 male,BALB/CByJ,strain, dorsal root ganglion tissue
GSM1612368 male,129S1/Sv1mJ,strain, dorsal root ganglion tissue
BioProject PRJNA275654

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65997_RAW.tar 292.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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