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| Status |
Public on Apr 27, 2015 |
| Title |
Innate lymphoid cell development requires TOX-dependent generation of a common ILC progenitor |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Subtypes of innate lymphoid cells (ILC), defined by effector function and transcription factor expression, have recently been identified. In the adult, ILC derive from common lymphoid progenitors in bone marrow, although transcriptional regulation of the developmental pathways involved remains poorly defined. TOX is required for development of lymphoid tissue inducer cells, a type of ILC3 required for lymph node organogenesis, and NK cells, a type of ILC1. We show here that production of multiple ILC lineages requires TOX, as a result of TOX-dependent development of common ILC progenitors. Comparative transcriptome analysis demonstrated failure to induce various aspects of the ILC gene program in the absence of TOX, implicating this nuclear factor as a key early determinant of ILC lineage specification.
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| Overall design |
TOX KO vs. wild tyype
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| Contributor(s) |
Seehus C, Aliahmad P, de la Torre B, Iliev I, Spurka L, Funari V, Kaye J |
| Citation(s) |
25915732 |
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| Submission date |
Feb 11, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Wolf Wiedemeyer |
| Organization name |
Cedars-Sinai
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| Department |
BMS
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| Street address |
8700 Beverly Blvd.
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| City |
Los Angeles |
| State/province |
California |
| ZIP/Postal code |
90048 |
| Country |
USA |
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| Platforms (1) |
| GPL18635 |
Ion Torrent Proton (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA275226 |
| SRA |
SRP054249 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE65850_FPKM_data.xlsx |
3.0 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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