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Series GSE65147 Query DataSets for GSE65147
Status Public on Jan 22, 2015
Title Time course of prion infected (RML) and globular domain ligands (POM1) in cultured organotypic cerebellar slices (COCS)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cultured organotypic cerebellar slices were exposed for different time points with either prions (RML) versus non-infectious brain homogenate (NBH) or ligands to the globular domain of the prion protein (POM1) vs IgG
 
Overall design We used microarrays to characterize the temporal response of two inducers prion protein dependent cell death: COCS were exposed to RML prions or Non-infectious brain homogenate (NBH) and harvested after 14d, 25d, 38d and 45d (4 replicates each condition). COCS were exposed to POM1 or IgG and harvested after 8h, 1d, 3d, 7d, 10d (4 replicates each condition).
 
Contributor(s) Herrmann US, Sonati T, Falsig J, Reimann RR, Dametto P, O'Connor T, Li B, Lau A, Hornemann S, Sorce S, Wagner U, Sanoudou D, Aguzzi A
Citation(s) 25710374
Submission date Jan 21, 2015
Last update date Feb 11, 2019
Contact name Ulrich Wagner
Organization name Uiversity Hospital Zurich
Street address Schmelzbergstrasse 12
City Zurich
ZIP/Postal code 8091
Country Switzerland
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (72)
GSM1588130 COCS exposed to IgG for 8h replicate 1
GSM1588131 COCS exposed to IgG for 8h replicate 2
GSM1588132 COCS exposed to IgG for 8h replicate 3
Relations
BioProject PRJNA273279

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE65147_RAW.tar 292.8 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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