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Series GSE64862 Query DataSets for GSE64862
Status Public on Jul 03, 2015
Title Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature [ChIP-Seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We performed genome-wide DNaseI hypersensitive site in FLT3-ITD and WT patient samples. We report corresponding gene expression, promoter methylation patterns of differential DHSs as well as differentially occupied TF binding motifs using surrounding DNAseI cut profiles. We examined association patterns of FLT3 ITD and WT AMLs and found that FLT3-ITD signaling is associated with common gene expression and chromatin signature.
 
Overall design Examination of Runx1 binding sites in FLT3 ITD AML.
 
Contributor(s) Cauchy P, James S, Ptasinska A, Zacarias-Cabeza J, Imperato MR, Assi S, Piper J, Ott S, Bonifer C, Cockerill P
Citation(s) 26212328
Submission date Jan 12, 2015
Last update date May 15, 2019
Contact name Pierre Daniel Cauchy
E-mail(s) cauchy@ie-freiburg.mpg.de
Phone +49 (0)761 5108-730
Organization name Max Planck Institute of Immunobiology and Epigenetics
Department Department of Cellular and Molecular Immunology
Lab Laboratory Rudolf Grosschedl
Street address St├╝beweg 51
City Freiburg
State/province Baden-W├╝rttemberg
ZIP/Postal code 79108
Country Germany
 
Platforms (2)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM1581788 ITD1_Runx1_ChIP-Seq
GSM1690574 MV4/11_siMM_cFos_ChIP-Seq
GSM1690575 MV4/11_siFLT3_cFos_ChIP-Seq
This SubSeries is part of SuperSeries:
GSE64874 Chronic growth factor signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature
Relations
BioProject PRJNA272428
SRA SRP052033

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE64862_RAW.tar 293.3 Mb (http)(custom) TAR (of WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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