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| Status |
Public on Dec 12, 2006 |
| Title |
Acne lesion vs. normal skin. Also includes non-acne patients' normal skin samples. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. Skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. Biopsies were also taken from normal skin of six subjects without acne. Gene array expression profiling was conducted using Affymetrix HG-U133A 2.0 arrays comparing lesional to nonlesional skin in acne patients and comparing nonlesional skin from acne patients to skin from normal subjects. Within the acne patients, 211 genes are upregulated in lesional skin compared to nonlesional skin. A significant proportion of these genes are involved in pathways that regulate inflammation and extracellular matrix remodeling, and they include matrix metalloproteinases 1 and 3, IL-8, human beta-defensin 4, and granzyme B. These data indicate a prominent role of matrix metalloproteinases, inflammatory cytokines, and antimicrobial peptides in acne lesions. These studies are the first describing the comprehensive changes in gene expression in inflammatory acne lesions and are valuable in identifying potential therapeutic targets in inflammatory acne.
Keywords: acne lesion, normal skin
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| Overall design |
total 18 chips. 6 for acne lesion samples, 6 for normal skin samples, 6 for non-acne patient normal skin samples
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| Contributor(s) |
Thiboutot DM |
| Citation(s) |
16528362 |
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| Submission date |
Dec 07, 2006 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Wei Zhao |
| E-mail(s) |
wuz4@psu.edu
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| Phone |
717 531 1262
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| Organization name |
Penn State University
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| Street address |
600 Centerview Drive, A210
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| City |
Hershey |
| State/province |
PA |
| ZIP/Postal code |
17033 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA98713 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE6475_RAW.tar |
57.2 Mb |
(http)(custom) |
TAR (of CEL) |
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