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Series GSE63736 Query DataSets for GSE63736
Status Public on Feb 18, 2016
Title Genome wide binding sites of NF-κB subunits RelA, RelB, p50, and p52 in the Hodgkin lymphoma cell line L1236
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The malignant cells of Hodgkin's lymphoma are characterized by a constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We carried out genome-wide localization and expression profiling experiments in the Hodgkin lymphoma cell line L1236 for the canonical and non-canonical NF-κB pathway components p65, p50 and p52, RelB, respectively. We found that the single NF-κB subunits bind to overlapping, but distinct cistromes by using consensus motifs of high similarity.
Overall design ChIP-Seq analysis of 4 NF-κB subunits with 2 biological replicates each
Contributor(s) Kärgel E, Heinig M, Patone G, Huebner N, Scheidereit C
Citation(s) 26988706
Submission date Dec 01, 2014
Last update date May 15, 2019
Contact name Marina Kolesnichenko
Organization name Max-Delbrück-Center
Lab Signal Transduction in Tumor Cells
Street address Robert-Rössle-Str. 10
City Berlin
ZIP/Postal code 13125
Country Germany
Platforms (2)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (14)
GSM1556331 RelA_ChIPSeq_rep1
GSM1556332 RelA_ChIPSeq_rep2
GSM1556333 RelB_ChIPSeq_rep1
BioProject PRJNA268947
SRA SRP050375

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63736_L1236_nfkb_peaks.txt.gz 1.6 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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