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Series GSE63664 Query DataSets for GSE63664
Status Public on Nov 14, 2016
Title Gene expression induced by DOT1L and Menin inhibition in cell line models of leukemia
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Gene expression upon DOT1L inhibition, or Menin inhibition, or a combination of DOT1L and Menin inhibiting agents, was assessed in several MLL-rearranged human cell lines and a mouse model of MLL-AF9 leukemia.
The goal of the study was to explore the mechanisms by which the EPZ0004777 and MI-2-2 chemicals collaborate to induce differentiation and cell death in MLL-AF4 and MLL-AF9 leukemias.
 
Overall design 2 compounds and combinaison thereof, 1 concentration & 1 timepoint per treatment, DMSO control, 3 biological replicates
 
Contributor(s) Craig VJ, Tiedt R, Gaulis S
Citation(s) 27840424
Submission date Nov 26, 2014
Last update date Feb 11, 2019
Contact name Swann Gaulis
E-mail swann.gaulis@novartis.com
Organization name Novartis Institutes for Biomedical Research
Department Oncology Research
Street address Postfach
City Basel
ZIP/Postal code 4002
Country Switzerland
 
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (56)
GSM1554911 RS4;11, Combo treat, biol rep 1
GSM1554912 RS4;11, Combo treat, biol rep 2
GSM1554913 RS4;11, Combo treat, biol rep 3
Relations
BioProject PRJNA268658

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63664_RAW.tar 258.9 Mb (http)(custom) TAR (of CEL)
GSE63664_excluded_CEL_files.tar.gz 19.0 Mb (ftp)(http) TAR
Raw data provided as supplementary file
Processed data included within Sample table

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