GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE63664 Query DataSets for GSE63664
Status Public on Nov 14, 2016
Title Gene expression induced by DOT1L and Menin inhibition in cell line models of leukemia
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Gene expression upon DOT1L inhibition, or Menin inhibition, or a combination of DOT1L and Menin inhibiting agents, was assessed in several MLL-rearranged human cell lines and a mouse model of MLL-AF9 leukemia.
The goal of the study was to explore the mechanisms by which the EPZ0004777 and MI-2-2 chemicals collaborate to induce differentiation and cell death in MLL-AF4 and MLL-AF9 leukemias.
Overall design 2 compounds and combinaison thereof, 1 concentration & 1 timepoint per treatment, DMSO control, 3 biological replicates
Contributor(s) Craig VJ, Tiedt R, Gaulis S
Citation(s) 27840424
Submission date Nov 26, 2014
Last update date Feb 11, 2019
Contact name Swann Gaulis
Organization name Novartis Institutes for Biomedical Research
Department Oncology Research
Street address Postfach
City Basel
ZIP/Postal code 4002
Country Switzerland
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (56)
GSM1554911 RS4;11, Combo treat, biol rep 1
GSM1554912 RS4;11, Combo treat, biol rep 2
GSM1554913 RS4;11, Combo treat, biol rep 3
BioProject PRJNA268658

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63664_RAW.tar 258.9 Mb (http)(custom) TAR (of CEL)
GSE63664_excluded_CEL_files.tar.gz 19.0 Mb (ftp)(http) TAR
Raw data provided as supplementary file
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap