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Series GSE63257 Query DataSets for GSE63257
Status Public on Jan 03, 2016
Title Subtype Specific Addiction of the Activated B Cell Subset of Diffuse Large B Cell Lymphoma to FOXP1
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Genome wide transcript and target gene profiling reveal that FOXP1 acts directly and indirectly by enforcing known ABC-DLBCL hallmarks, including Chronically Activated B cell receptor Signaling (CABS) and the classical NF-κB survival pathway. Our data further suggest that FOXP1 maintains ABC-subtype distinction by repressing gene expression programs dominant in GCB-DLBCL and support a model in which the normally transitory B cell plasmablast is the target of ABC-DLBCL transformation.
Overall design ChIP sequenicng was performed for the FOXP1 transcription factor in DLBCL cell lines. Input was sequenced and used as a control.
Contributor(s) Tucker H, Iyer VR
Citation(s) 26787899
Submission date Nov 13, 2014
Last update date May 15, 2019
Contact name Vishy Iyer
Phone 5122327833
Organization name University of Texas at Austin
Department Institute for Cell and Molecular Biology
Street address 2500 Speedway Dr. MBB 3.212
City Austin
State/province TX
ZIP/Postal code 78712
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (14)
GSM1544531 bjab_foxp1
GSM1544532 bjab_input
GSM1544533 hbl_foxp1
BioProject PRJNA267114
SRA SRP049768

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63257_RAW.tar 1.2 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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