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Series GSE63257 Query DataSets for GSE63257
Status Public on Jan 03, 2016
Title Subtype Specific Addiction of the Activated B Cell Subset of Diffuse Large B Cell Lymphoma to FOXP1
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Genome wide transcript and target gene profiling reveal that FOXP1 acts directly and indirectly by enforcing known ABC-DLBCL hallmarks, including Chronically Activated B cell receptor Signaling (CABS) and the classical NF-κB survival pathway. Our data further suggest that FOXP1 maintains ABC-subtype distinction by repressing gene expression programs dominant in GCB-DLBCL and support a model in which the normally transitory B cell plasmablast is the target of ABC-DLBCL transformation.
 
Overall design ChIP sequenicng was performed for the FOXP1 transcription factor in DLBCL cell lines. Input was sequenced and used as a control.
 
Contributor(s) Tucker H, Iyer VR
Citation(s) 26787899
Submission date Nov 13, 2014
Last update date May 15, 2019
Contact name Vishy Iyer
E-mail(s) iyerlab@gmail.com
Phone 5122327833
Organization name University of Texas at Austin
Department Institute for Cell and Molecular Biology
Street address 2500 Speedway Dr. MBB 3.212
City Austin
State/province TX
ZIP/Postal code 78712
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (14)
GSM1544531 bjab_foxp1
GSM1544532 bjab_input
GSM1544533 hbl_foxp1
Relations
BioProject PRJNA267114
SRA SRP049768

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63257_RAW.tar 1.2 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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