|
| Status |
Public on Oct 01, 2015 |
| Title |
Androgen receptor DNA binding in response to different ligands across three prostate cancer cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We performed AR ChIP-seq in LNCaP-AR, VCaP and CWR22PC cells in the presence of vehicle, androgen, or androgen plus antiandrogen. These three cell lines showed variable sensitivity to these drugs.
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| |
|
| Overall design |
To determine the effects of AR agonist (R1881 vs DHT) and antagonists (Bicalutamide vs MDV3100) on the AR cistrome across a panel of prostate cancer cell lines.
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| |
|
| Contributor(s) |
Cai L, Zheng D, Sawyers CL |
| Citation missing |
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| |
| Submission date |
Oct 16, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Yu Chen |
| E-mail(s) |
cheny1@mskcc.org
|
| Phone |
646-888-3356
|
| Organization name |
Memorial Sloan Kettering Cancer Center
|
| Department |
Human Oncology and Pathogenesis Program
|
| Lab |
Chen
|
| Street address |
1275 York Ave, Box 20
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL9442 |
AB SOLiD System 3.0 (Homo sapiens) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (15)
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| This SubSeries is part of SuperSeries: |
| GSE62472 |
Cell context specific effect of AR antagonists on AR DNA binding and target gene expression |
|
| Relations |
| BioProject |
PRJNA264098 |
| SRA |
SRP048997 |
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