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Series GSE62425 Query DataSets for GSE62425
Status Public on Sep 30, 2015
Title Delineating the Transcriptional Network of Prognostic Gene Signatures Refines Treatment Recommendations for Lymph Node-negative Breast Cancer Patients
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We performed Chip-Seq analyses of several DNA binding transcription factors predicted to function as "master transcriptional regulators" (MTRs) of breast cancer prognostic gene signatures in primary human mammary epithelial cells (HMECs). These analyses demonstrated that these factors frequently co–bind the promoters of genes, the expression of which is associated with a proliferative phenotype and poor patient outcome. These data suggest that these predicted MTRs do indeed drive the expression of gene signatures associated with poor patient outcome in breast cancer.
 
Overall design Examination of the genome–wide binding of breast cancer prognostic/proliferative transcription factors in proliferating breast cells.
 
Contributor(s) Bracken AP, Brien GL, Hokamp K
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Submission date Oct 16, 2014
Last update date May 15, 2019
Contact name Karsten Hokamp
E-mail(s) kahokamp@tcd.ie
Phone +35318962719
Organization name Trinity College Dublin
Department Smurfit Institute of Genetics
Street address College Green
City Dublin
ZIP/Postal code 2
Country Ireland
 
Platforms (1)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
Samples (4)
GSM1526873 input DNA
GSM1526874 FOXM1_ChIPSeq
GSM1526875 MYBL2_ChIPSeq
Relations
BioProject PRJNA264075
SRA SRP048986

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62425_RAW.tar 578.1 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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