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Series GSE62020 Query DataSets for GSE62020
Status Public on Sep 25, 2020
Title Rod photoreceptors degeneration in the rd1 model of retinitis pigmentosa involves a cascade of events leading to proteasome dysfunction
Organism Mus musculus
Experiment type Expression profiling by array
Summary Retinitis pigmentosa is an inherited disease with sequential retinal degeneration of rod then cone photoreceptors leading to blindness. As in this human syndrome the rd1 mouse model carries a recessive mutation in the rod-specific cGMP phosphodiesterase beta subunit gene leading to rod followed by cone photoreceptor death. The cascade of early events leading to the induction of rod cell death through apoptosis remains unknown.
We report a differential whole-genome expression profiling analysis of the wild-type and rd1 mouse retinal transcriptional program using high-density oligonucleotide microarrays with a time series experiment spanning the entire rod photoreceptor degeneration process. Among the 1252 genes found to be significantly differentially expressed, a key group of 19 loci showed distinct differences in expression early in development, suggesting that these genes of clinical interest may play a fundamental role in the induction of the rod photoreceptor degeneration.
Overall design Samples from purified retinal RNA from mice aged at different post-natal days were taken
Contributor(s) Clérin E, Delalande F, Chalmel F, Perrocheau L, Aït-Ali N, Thiersé D, Millet-Puel G, Langelé A, Niepon M, Raffelsberger W, Berdugo N, Jaillard C, Mohand-Saïd S, Fraulob V, Robert F, Gofflot F, Dollé P, Lambrou G, Primig M, Ripp R, Zack DJ, Sahel J, Poch O, Van Dorsselaer A, Léveillard T
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Submission date Oct 03, 2014
Last update date Sep 26, 2020
Contact name Frederic Blond
Organization name Institut de la Vision
Street address 17 rue Moreau
City Paris
ZIP/Postal code 75012
Country France
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (54)
GSM1518508 Retina from C3H WT mice, PN5, biological rep 1
GSM1518509 Retina from C3H WT mice, PN5, biological rep 2
GSM1518510 Retina from C3H rd1 mice, PN5, biological rep 1
BioProject PRJNA262966

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62020_RAW.tar 342.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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