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Series GSE61659 Query DataSets for GSE61659
Status Public on May 01, 2015
Title Cross-species genomics identifies postanatal CPE as novel choroid plexus carcinoma oncogenes.
Organism Mus musculus
Experiment type Expression profiling by array
Summary Choroid plexus carcinomas (CPC) are poorly understood and frequently lethal brain tumors with minimal treatment options. Using a new mouse model of the disease and a large cohort of human CPCs [GSE60892; GSE60899], we performed a cross-species, genome-wide search for novel oncogenes within syntenic regions of chromosome gain. TAF12, NFYC and RAD54L, co-located on human chromosome 1p32-35.3 and mouse chromosome 4qD1-D3, were identified as oncogenes that are gained in tumors in both species and required to initiate and progress the disease in mice. TAF12 and NFYC are transcription factors that regulate the epigenome, while RAD54L plays a central role in DNA repair. Our data identify a group of concurrently gained, novel oncogenes that cooperate in the formation of CPC and unmask potential new avenues for therapy.
 
Overall design CPC mouse model samples of tumors derived from choroid plexus epithelium (CPE) cells that are Tp53/RB/Pten null in FVB mice. Female CD1 nude (host) mice were transfected with postanatal CPE and compared with a medulloblastoma normal mouse embryonic, postnatal and adult controls (loxP TP53/RB/PTEN (no Cre))
Implanted and reimplanted are from the orthotropic transplants of the primary tumor or later tumors
 
Contributor(s) Tong Y, Marino D, Nimmervoll B, Gupta K, Wang M, Finkelstein D, Dalton J, Ellison DW, Zhang J, Malkin D, Gilbertson RJ
Citation(s) 25965574
Submission date Sep 23, 2014
Last update date Feb 11, 2019
Contact name David Finkelstein
E-mail david.finkelstein@stjude.org
Phone 9014953931
Organization name St Jude Children's Research Hospital
Department Computational Biology
Street address 332 N. Lauderdale St.
City Memphis
State/province TN
ZIP/Postal code 38105
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (57)
GSM1510154 yto001
GSM1510155 yto002
GSM1510156 yto003
Relations
BioProject PRJNA261821

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61659_RAW.tar 204.0 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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