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Series GSE61524 Query DataSets for GSE61524
Status Public on Mar 31, 2015
Title The Sinorhizobium meliloti SyrM regulon: effects on global gene expression are mediated by syrA and nodD3 (SyrA)
Platform organisms Sinorhizobium meliloti; Medicago truncatula
Sample organism Sinorhizobium meliloti
Experiment type Expression profiling by array
Summary We characterized transcriptomes of a strain overexpressing syrA. Our work shows that the syrA transcriptome shares similar gene expression changes to the syrM and nodD3 transcriptomes and that nodD3 and syrA may be the only targets directly activated by SyrM. We propose that most of the gene expression changes observed when nodD3 is overexpressed are due to NodD3 activation of syrM expression, which in turn stimulates SyrM activation of syrA expression. The subsequent increase in SyrA abundance alters activity of the ChvI-ExoS-ExoR circuit, resulting in broad changes in gene expression.
 
Overall design Gene expression profiling of Sinorhizobium meliloti overexpressing syrA was performed using custom Affymetrix GeneChips
 
Contributor(s) Barnett MJ, Long SR
Citation(s) 25777671
Submission date Sep 18, 2014
Last update date Jun 12, 2015
Contact name Melanie J Barnett
E-mail(s) melbar@stanford.edu
Organization name Stanford University
Department Biology
Lab Sharon R. Long
Street address 371 Serra Mall
City Stanford
State/province CA
ZIP/Postal code 94089
Country USA
 
Platforms (1)
GPL9757 [stSmel_Mtra] SRL_SU Sinorhizobium meliloti/Medicago truncatula dual-genome SymbiosisChip, Affymetrix part number 510699
Samples (6)
GSM1507426 Sinorhizobium meliloti Rm1021 pMB90, biological rep1
GSM1507427 Sinorhizobium meliloti Rm1021 pMB90, biological rep2
GSM1507428 Sinorhizobium meliloti Rm1021 pMB90, biological rep3
This SubSeries is part of SuperSeries:
GSE61526 The Sinorhizobium meliloti SyrM regulon: effects on global gene expression are mediated by syrA and nodD3
Relations
BioProject PRJNA261382

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61524_RAW.tar 23.4 Mb (http)(custom) TAR (of CEL)
SRA Run SelectorHelp
Raw data provided as supplementary file
Processed data included within Sample table

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