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Series GSE60792 Query DataSets for GSE60792
Status Public on Apr 11, 2016
Title ChIP-seq of erythroid progenitors treated with vehicle or the HDAC1/2-selective inhibitor ACY-957
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Establish the DNA binding profiles of HDAC1, HDAC2 and Gata2 in erythroid progenitors derived from human CD34+ bone marrow cells. Determine the effects of HDAC1/2 inhibition on the DNA binding profiles of Gata2.
Overall design 5 samples in total. Cells have either been treated with vehicle or ACY-957 (an HDAC1/2 selective inhibitor) prior to immunoprecipitation. Sample 1 is chromatin from vehicle treated cells immunoprecipitated with anti-HDAC1 antibody. Sample 2 is chromatin from vehicle treated cells immunoprecipitated with anti-HDAC2 antibody. Sample 3 and 4 are chromatin from vehicle treated or ACY-957 treated cells immunoprecipitated with anti-Gata2, respectively. Sample 5 is the input sample, which is a mix of non-immunoprecipitated chromatin from vehicle treated and ACY-957 treated cells.
Contributor(s) Shearstone JR, Golonzhka O, Chonkar A, Tamang D, van Duzer JH, Jones SS, Jarpe MB
Citation(s) 27073918
Submission date Aug 26, 2014
Last update date May 15, 2019
Contact name Jeff Shearstone
Phone 617-245-1321
Organization name Acetylon Pharmaceuticals
Department Biology
Street address 70 Fargo Street
City Boston
State/province MA
ZIP/Postal code 02210
Country USA
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (5)
GSM1488755 HDAC1-IP_vehicle
GSM1488756 HDAC2-IP_vehicle
GSM1488757 Gata2-IP_vehicle
This SubSeries is part of SuperSeries:
GSE60793 Chemical inhibition of Histone Deacetylases 1 and 2 induces fetal hemoglobin through activation of Gata2
BioProject PRJNA259552
SRA SRP045797

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Supplementary file Size Download File type/resource
GSE60792_RAW.tar 758.9 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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