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| Status |
Public on Aug 26, 2014 |
| Title |
Central Role of ULK1 in Type I Interferon Signaling |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We provide evidence that the Unc-51-like kinase 1 (ULK1) is phosphorylated and activated during engagement of the Type I IFN receptor. Our studies demonstrate that the function of ULK1 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, including anti-viral and antineoplastic responses.
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| Overall design |
Total RNA was isolated from untreated and IFNβ-treated Ulk1/2+/+ and Ulk1/2-/- mouse embryonic fibroblasts (MEFs). Cells were treated for 6 hours with or without mouse IFNβ (2500 IU/ml).
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| Contributor(s) |
Saleiro D, Lisowski P, Platanias LC |
| Citation(s) |
25892232 |
| |
| Submission date |
Aug 26, 2014 |
| Last update date |
Oct 10, 2019 |
| Contact name |
Pawel Lisowski |
| E-mail(s) |
pawel.lisowski@mdc-berlin.de
|
| Phone |
+493094061370
|
| Organization name |
Max-Delbrück-Center for Molecular Medicine (MDC) in the Helmholtz Association
|
| Street address |
Hannoversche Str. 28
|
| City |
Berlin |
| ZIP/Postal code |
10115 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA259538 |
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