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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 01, 2015 |
| Title |
Stretch-dependent genes in vascular smooth muscle cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Vascular smooth muscle cells (VSMCs) respond to biomechanical stretch with specific changes in gene expression which govern the phenotype of these cells. The mechanotransducer zyxin is a
potential candidate for regulating the expression of such genes. Using microarrays, we compared stretch-induced gene expression in wild type and zyxin-null VSMCs to define such changes in detail.
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| Overall design |
Wild type (WT) and zyxin-null VSMCs were stretched at 10% cyclic elongation for 6 hours and the changes in gene expression were compared under static and stretched conditions. Up to 3 biological replicates were used for each of the 4 sample types.
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| Contributor(s) |
Ghosh S, Hecker M |
| Citation(s) |
26071033 |
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| Submission date |
Aug 15, 2014 |
| Last update date |
Jul 01, 2015 |
| Contact name |
Carsten Sticht |
| Organization name |
University Heidelberg
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| Department |
ZMF
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| Street address |
Theodor-Kutzer-Ufer
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| City |
Mannheim |
| ZIP/Postal code |
68169 |
| Country |
Germany |
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| Platforms (1) |
| GPL18615 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENTREZG.cdf Brainarray version 17.0.0] |
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| Samples (11)
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| GSM1480250 |
Zyxin-null VSMCs, static, biological rep1 |
| GSM1480251 |
Zyxin-null VSMCs, static, biological rep3 |
| GSM1480252 |
Wild type VSMCs, static, biological rep1 |
| GSM1480253 |
Wild type VSMCs, static, biological rep2 |
| GSM1480254 |
Wild type VSMCs, static, biological rep3 |
| GSM1480255 |
Wild type VSMCs, stretched, biological rep1 |
| GSM1480256 |
Wild type VSMCs, stretched, biological rep2 |
| GSM1480257 |
Wild type VSMCs, stretched, biological rep3 |
| GSM1480258 |
Zyxin-null VSMCs, stretched, biological rep1 |
| GSM1480259 |
Zyxin-null VSMCs, stretched, biological rep2 |
| GSM1480260 |
Zyxin-null VSMCs, stretched, biological rep3 |
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| Relations |
| BioProject |
PRJNA258283 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE60447_RAW.tar |
77.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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