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Series GSE60379 Query DataSets for GSE60379
Status Public on May 14, 2015
Title Gene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regulatory network. The regulation networks between the p53 tumor suppressor and lncRNAs in nasopharyngeal carcinoma (NPC) remain unclear. The aim of this study was to investigate the regulatory roles of the TP53 gene in regulating lncRNA and mRNA expression profiles in NPC cell line HNE2.
Overall design p53 induced gene expression in human nasopharyngeal carcinoma cell line HNE2 was measured at 0, 12, 24 and 48 hours after transfected by pCMV-p53 plasmid.
Contributor(s) Xiong W, Zeng Z, Gong Z, Zhang S, Xiong F, Zeng Y, Li X, Li G
Citation(s) 25422887
Submission date Aug 13, 2014
Last update date May 16, 2015
Contact name Wei Xiong
Organization name Central South University
Department Cancer Research Institute
Street address 110 Xiangya Road
City Changsha
State/province Hunan
ZIP/Postal code 410078
Country China
Platforms (1)
GPL19061 Agilent-043965 custom human array oelinc_xw
Samples (4)
GSM1477452 HNE2_TP53 transfection_0 hour
GSM1477453 HNE2_TP53 transfection_12 hours
GSM1477454 HNE2_TP53 transfection_24 hours
BioProject PRJNA258153

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Supplementary file Size Download File type/resource
GSE60379_RAW.tar 111.8 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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