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Series GSE60009 Query DataSets for GSE60009
Status Public on Oct 24, 2014
Title Candidate Vaccine Assessment in a pH1N1 Rhesus Macaque Challenge Model
Platform organism Homo sapiens
Sample organism Macaca mulatta
Experiment type Expression profiling by array
Summary A mixed-aerosol pH1N1 (Cal04) challenge of rhesus macaques was establised to serve as a pre-clinical model for the evaluation of candidate vaccines. After characterizing the clinical signs and immune responses associated with pH1N1 challenge in naïve rhesus macaques, a follow-up study assessing 2 candidate vaccines was performed.
 
Overall design This study has 2 phases: 1) Model Establisment consisting of 3 groups: Unvaccinated Live Challenge (n=3, Unvaccinated UV-inactivated Challenge (n=3), Previously Vaccinated Live Challenge (n=3) which were sampled at 2 baseline timepoints Day -7 and Day 0. Following the H1N1 Challenge, samples were collected at day 1,2,5,8,14,20. 2) Candidate Vaccine Assessment consisting of four groups: Previously Vaccinted with anti-CD40-NP5+PolyICLC (n=4), Previously vaccinated with CD40-HA+PolyICLC (n=4), Previously vaccinated with commercial mismatched Fluzone (n=4), Previously vaccinated with Media+PolyICLC alone (n=4). Daseline samples were collected at Day -7 and 0 (baseline) and Day 1,3,6,14,20 post-challenge.
 
Contributor(s) Skinner JA
Citation(s) 25298110
Submission date Aug 01, 2014
Last update date Aug 13, 2018
Contact name Jason A Skinner
E-mail(s) jaskinner06@yahoo.com
Organization name Baylor Institute for Immunology Research
Street address 3434 Live Oak
City Dallas
State/province TX
ZIP/Postal code 75204
Country USA
 
Platforms (1)
GPL10558 Illumina HumanHT-12 V4.0 expression beadchip
Samples (171)
GSM1463472 HF29(2)L
GSM1463473 HH69(2)L(Vac)
GSM1463474 HE19(14)L
Relations
BioProject PRJNA257270

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE60009_Matrix_ModelEstablishment_Normalized.txt.gz 20.2 Mb (ftp)(http) TXT
GSE60009_Matrix_VaccineAssesement_Normalized.txt.gz 35.0 Mb (ftp)(http) TXT
GSE60009_ModelEstablishment_Non-normalized.txt.gz 18.7 Mb (ftp)(http) TXT
GSE60009_RAW.tar 26.2 Mb (http)(custom) TAR
GSE60009_VaccineAssesement_Non-normalized.txt.gz 30.9 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table
Processed data are available on Series record

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