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| Status |
Public on Jul 14, 2014 |
| Title |
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma [expression] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Transcriptional profiling of two pediatric human DIPG cell lines, harboring the K27M mutation. DIPG cell lines were treated with GSKJ4 for 24 and 72 h. The untreated cell lines served as baseline, and expression fold changes in each treated cell line were determined relative to the baseline. Goal was to determine the effects of GSKJ4 treatment on global gene expression in DIPG cells harboring the K27M mutation.
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| Overall design |
Three-condition experiment: 72 h GSKJ4 treated cells vs. 24 h GSKJ4 treated cells vs. untreated cells. Biological replicates: 1 cell line, with 2 technical replicates per condition.
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| Contributor(s) |
Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris P, Zhang Z, Petritsch C, Gupta N, Waldman T, James CD |
| Citation(s) |
25401693 |
| |
| Submission date |
Jul 13, 2014 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Rintaro Hashizume |
| E-mail(s) |
rintaro.hashizume@ucsf.edu
|
| Organization name |
UCSF
|
| Department |
Neurosurgery
|
| Street address |
1450 3rd street
|
| City |
San Francisco |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (4)
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| GSM1435827 |
DIPG cell line 2 treated with GSK4 24h post treatment replicate 1 |
| GSM1435828 |
DIPG cell line 2 treated with GSK4 24h post treatment replicate 2 |
| GSM1435829 |
DIPG cell line 2 treated with GSK4 72h post treatment replicate 1 |
| GSM1435830 |
DIPG cell line 2 treated with GSK4 72h post treatment replicate 2 |
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| This SubSeries is part of SuperSeries: |
| GSE59497 |
Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma |
|
| Relations |
| BioProject |
PRJNA255190 |
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