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Series GSE58752 Query DataSets for GSE58752
Status Public on Feb 18, 2015
Title Integrative analysis of haplotype-resolved epigenomes across human tissues
Organism Homo sapiens
Experiment type Other
Summary Allelic differences between the two sets of chromosomes can affect the propensity of inheritance in humans, but the extent of such differences in the human genome has yet to be fully explored. Here, we delineate allelic chromatin modifications and transcriptomes amongst a broad set of human tissues, enabled by a chromosome-span haplotype reconstruction strategy1. The resulting haplotype-resolved epigenomic maps reveal extensive allele bias in the transcription of human genes as well as chromatin state, allowing us to infer cis-regulatory relationships between genes and their control sequences. These maps also uncover a new class of cis regulatory elements and detail activities of repetitive elements in various human tissues. The rich datasets described here will enhance our understanding of the mechanisms controlling tissue-specific gene expression programs.
 
Overall design One replicate of Hi-C experiment in four human tissues with four different individuals (Thymus STL001, Aorta STL002, Leftventricle STL003, and Liver STL011).
 
Contributor(s) Jung I, Schmitt A, Leung D, Ren B
Citation(s) 25693566
Submission date Jun 24, 2014
Last update date May 15, 2019
Contact name Inkyung Jung
E-mail(s) ijungkaist@gmail.com
Organization name KAIST
Department Biological Sciences
Street address KAIST, 291 Daehak-ro, Yuseong-gu
City Daejeon
ZIP/Postal code 34141
Country South Korea
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (4)
GSM1419083 Hi-C, Thymus STL001, replicate one
GSM1419084 Hi-C, Aorta STL002, replicate one
GSM1419085 Hi-C, LeftVentricle STL003, replicate one
Relations
BioProject PRJNA253910
SRA SRP043660

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58752_RAW.tar 49.0 Mb (http)(custom) TAR (of VCF)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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