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| Status |
Public on Dec 22, 2014 |
| Title |
Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature (ChIP-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We report the application of high-throughput sequencing to performed the p53 regulated trancriptome in HCT116 colon cancer cells treated with the DNA damage 5FU. To study the direct targets of p53 we performed ChIP-seq to deterrmined the p53 biding sites and associated with the expression levels. With this study we identified the new genomic regions regulated by p53 and with special attention in those regions that are non coding and are differentially expressed by the DNA damage drug.
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| |
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| Overall design |
Description of the p53 transcriptome in HCT116 colon cancer cell line
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| |
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| Contributor(s) |
Huarte M, Sanchez Y, Segura V |
| Citation(s) |
25524025 |
| |
| Submission date |
Jun 15, 2014 |
| Last update date |
May 15, 2019 |
| Contact name |
Maite Huarte |
| E-mail(s) |
maitehuarte@unav.es
|
| Organization name |
CIMA
|
| Street address |
c/ Avd Pio XII, 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (2) |
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| This SubSeries is part of SuperSeries: |
| GSE58528 |
Genomewide analysis of the human p53 transcriptional network unveils a lncRNA tumor suppressor signature |
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| Relations |
| BioProject |
PRJNA252830 |
| SRA |
SRP043272 |
