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| Status |
Public on Jun 11, 2014 |
| Title |
Axiom® Exome 319 Array data to identify susceptible genetic variations of gastric cancer |
| Organism |
Homo sapiens |
| Experiment type |
SNP genotyping by SNP array
Genome variation profiling by SNP array
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| Summary |
To efficiently identify genetic susceptibility variants for gastric cancer, including rare coding variants, we performed an exome chip-based array study. We found that a linkage disequilibrium (LD) block containing 2 significant variants in PSCA gene increased the risk and two blocks that included 15 suggested variants including TRIM31, TRIM 40, TRIM 10, and TRIM26 regions, and included one suggested variant and OR2H2 gene showed protective associations with gastric cancer susceptibility. In addition, the PLEC region (rs200893203), FBLN2 region (rs201192415), and EPHA2 region (rs3754334) were associated with increased susceptibility
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| Overall design |
We performed an exome chip-based array study in 329 gastric cancer cases and 683 controls.
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| Contributor(s) |
Kim J, Park B, Lee J, Cho YA, Woo HD, Jeong SH, Lee JE, Shin ES, Choi IJ, Kim YW |
| Citation(s) |
30189721 |
| Submission date |
Jun 10, 2014 |
| Last update date |
Apr 16, 2022 |
| Contact name |
Boyoung Park |
| Organization name |
National Cancer Centerm Korea
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| Street address |
323 Ilsan-ro, Ilsandong-gu, Goyang-si
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| City |
Gyeonggi-do |
| ZIP/Postal code |
410-769 |
| Country |
South Korea |
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| Platforms (1) |
| GPL18760 |
[Axiom_Exome319] Affymetrix Human Axiom Exome 319 Genotyping Array |
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| Samples (1012)
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| Relations |
| BioProject |
PRJNA252114 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE58356_RAW.tar |
12.7 Gb |
(http)(custom) |
TAR (of CEL, CHP) |
| Raw data provided as supplementary file |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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