|
| Status |
Public on Jan 01, 2015 |
| Title |
RNA-Seq Identifies Novel Myocardial Gene Expression Signatures of Heart Failure [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have utilized the RNA-Seq technology to identify genes with distinct expression patterns between failing and non-failing hearts. In an era of next-generation sequencing studies, our study demonstrates how knowledge gained from a small set of samples with accurately measured gene expressions using RNA-Seq can be leveraged as a complementary strategy to discern the genetics of complex disorders.
|
| |
|
| Overall design |
Identify the signature genes based on RNA-seq come from six Heart Failure and healthy individuals. Validation is based on Affymetrix microarray of a total of 313 individuals with/without Heart Failure.
|
| |
|
| Contributor(s) |
Liu Y, Morley MP, Brandimarto J, Hannenhalli S, Hu Y, Ashley EA, Tang WH, Moravec CS, Margulies KB, Cappola T, Li M |
| Citation(s) |
25528681, 26134005 |
| |
| Submission date |
May 06, 2014 |
| Last update date |
Jun 10, 2019 |
| Contact name |
Michael Patrick Morley |
| E-mail(s) |
mmorley@pennmedicine.upenn.edu
|
| Phone |
215-898-2026
|
| Organization name |
Perelman School of Medicine at the University of Pennsylvania
|
| Department |
Penn Cardiovascular Institute
|
| Street address |
3400 Civic Center Blvd, Bldg 421
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
|
| Samples (6)
|
| GSM1380721 |
P00234 Ischemic Left Ventricle |
| GSM1380722 |
C02182 Idiopathic Dilated CMP Left Ventricle |
| GSM1380723 |
P00333 Idiopathic Dilated CMP Left Ventricle |
|
| This SubSeries is part of SuperSeries: |
| GSE57345 |
RNA-Seq Identifies Novel Myocardial Gene Expression Signatures of Heart Failure |
|
| Relations |
| BioProject |
PRJNA246308 |
| SRA |
SRP041706 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE57344_RAW.tar |
2.1 Mb |
(http)(custom) |
TAR (of FPKM_TRACKING) |
| GSE57344_gene_diff_C02182_C00111.txt.gz |
455.0 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_C02182_P01207.txt.gz |
448.3 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_C02182_P01256.txt.gz |
449.5 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_DCM_vs_NF.txt.gz |
492.6 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_ISCH_vs_NF.txt.gz |
470.1 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00234_C00111.txt.gz |
471.2 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00234_P01207.txt.gz |
470.0 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00234_P01256.txt.gz |
469.7 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00333_C00111.txt.gz |
459.6 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00333_P01207.txt.gz |
457.8 Kb |
(ftp)(http) |
TXT |
| GSE57344_gene_diff_P00333_P01256.txt.gz |
458.8 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
Less...
More...