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Series GSE56874 Query DataSets for GSE56874
Status Public on Jul 03, 2014
Title Gene expression profile of human cardiac fibroblasts (HCFs), induced cardiomyocytes (iCMs), and heart
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Global gene expression profile of total 24460 probes in the iCMs. The gene expression shifts from a fibroblast state toward a cardiac-like phenotype by Gata4/Mef2c/Tbx5/Mesp1/Myocd (GMTMM) or GMTMM/miR-133 transduction at 7 days after transduction.
MiR-133 silenced fibroblast signatures in parallel with cardiac gene activation, and Snai1 overexpression inhibited the effects of miR-133-mediated cardiac reprogramming.
 
Overall design HCFs were used for negative control, human heart tissue for positive control. Gene expression profiles were compared among HCFs, iCMs and heart. 24460 probes were analyzed in each experiment.
 
Contributor(s) Muraoka N, Ieda M
Citation(s) 24920580
Submission date Apr 17, 2014
Last update date Jul 03, 2014
Contact name Satoshi Kondo
E-mail(s) Satoshi_Kondou@nts.toray.co.jp
Organization name Toray Industries,Inc.
Department New Projects Development Division
Street address Tebiro 6-10-1
City Kamakura
State/province Kanagawa
ZIP/Postal code 248-8555
Country Japan
 
Platforms (1)
GPL13915 3D-Gene Human Oligo chip 25k V2.1
Samples (5)
GSM1370494 HCF
GSM1370495 Heart
GSM1370496 GMTMM
This SubSeries is part of SuperSeries:
GSE56913 Gene expression profiles of induced cardiomyocytes(iCMs)
Relations
BioProject PRJNA244923

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56874_RAW.tar 7.5 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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