|
| Status |
Public on Jun 10, 2014 |
| Title |
Expression data from human metastatic melanoma cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The genetic changes underlying metastatic melanoma need to be deciphered to develop new and effective therapeutics. Previously, genome-wide microarray analyses of human melanoma identified two reciprocal gene expression programs, that included expression of mRNAs regulated by either transforming growth factor, beta 1 (TGFB1) pathways or microphthalmia-associated transcription factor (MITF)/SRY-box containing gene 10 (SOX10) pathways. We extend this knowledge to include gene expression analyses of 5 additional human melanoma lines, and show that these lines also fall into either TGFB1 or MITF/SOX10 gene expression groups.
These mRNA expression studies were followed up by miRNA expression analyses.
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| |
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| Overall design |
Microarray analyses were performed on 5 metastatic melanoma lines in 3 replicates. Standard Affymetrix protocols were used.
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| Contributor(s) |
Hwang H, Baxter LL, Loftus SK, Cronin JC, Trivedi NS, Borate B, Pavan WJ |
| Citation(s) |
24767210 |
| |
| Submission date |
Apr 10, 2014 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Laura L Baxter |
| Organization name |
NIH
|
| Department |
NHGRI
|
| Lab |
PGTS/CPHR
|
| Street address |
35A Convent Drive
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA244359 |
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