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Series GSE56026 Query DataSets for GSE56026
Status Public on Mar 20, 2014
Title Gene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Endometrial cancer is one of the most common gynecologic malignancies, and patients with high grade disease, especially serous papillary subtype (SPEC) are often related to the poor outcomes. Recent genome-wide analyses have revealed that SPEC exhibits gene expression profiles that are distinct from the endometrioid histologic subtype; therefore, it is important to identify the SPEC driver genes or pathways responsible for the inherently aggressive phenotypes and to develop SPEC-specific therapies to target these driver genes or pathways.
Through array-based analysis and immunohistochemical staining of human endometrial cancer tissue, STAT1 is identified high expressed, and can distinguish SPEC from other subtypes of endometrial cancer. In vitro and in vivo experiments show STAT1 role as a pro-survival factor in SPEC. STAT1 was identified as a master gene modulating “transcriptional pro-survival pathways” to enhance multiple malignant characteristics These finding may suggest that targeting of STAT1, the SPEC driver gene, may provide the means to improve poor outcomes for patients with SPEC.
 
Overall design We used microarrays to clarify the changes of gene expression along with STAT1-siRNA treatment and to confirm whether there are any changes on genes expression related to STAT1 pathway. We also used the microarray data to clarify genes signatures which can distinguish subtype of human endometrial cancers.
 
Contributor(s) Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, Yamaguchi K, Hosoe Y, Yoshioka Y, Mandai M, Konishi I
Citation(s) 25267067
Submission date Mar 19, 2014
Last update date Mar 25, 2019
Contact name Budiman Kharma
E-mail(s) budimank@kuhp.kyoto-u.ac.jp
Phone +81-75-751-3269
Organization name Kyoto University Graduate School of Medicine
Department Gynecology and Obstetrics
Street address 54 Kawahara-cho, Shogoin, Sakyo-ku
City Kyoto
State/province Kyoto
ZIP/Postal code 606-8507
Country Japan
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (75)
GSM1350708 SPAC-1L_1
GSM1350709 SPAC-1L_2
GSM1350710 SPAC-1L_3
Relations
BioProject PRJNA242255

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56026_RAW.tar 376.2 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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