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| Status |
Public on Jun 03, 2015 |
| Title |
Gene expression profiles regulated by PLD1-E2F1 axis in two Wnt-relevant colon cancer cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
1. To identify potential effectors responsible for anti-tumorigenesis by targeting PLD1, we performed microarray in two Wnt-relevant colon cancer cells and analyzed transcriptional profile of genes that were differently expressed by inhibition and knockdown of PLD1
2. We also investigated potential downstream effectors of PLD1-E2F1 axis using microarray analysis in PLD1 and E2F1-depleted CRC cells.
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| |
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| Overall design |
Total RNA obtained from isolated DLD1 and HCT116 cells in shCTRL (Vehicle), shCTRL-PLD1-Inh, shPLD1, or shPLD1/shE2F1 groups under 1% serum condition for 36 hours, respectively.
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| |
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| Contributor(s) |
Min DS, Kang DW |
| Citation(s) |
26122663, 27793841 |
| |
| Submission date |
Mar 10, 2014 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Do Sik Min |
| E-mail(s) |
minds@pusan.ac.kr
|
| Phone |
82515103682
|
| Organization name |
Pusan National University
|
| Department |
Molecular Biology
|
| Lab |
208, Molecular Biomedical Science Research
|
| Street address |
30 Jangjeon-dong, Geumjeong-gu
|
| City |
Busan |
| ZIP/Postal code |
609735 |
| Country |
South Korea |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA240711 |
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