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Series GSE55489 Query DataSets for GSE55489
Status Public on Jun 03, 2014
Title Liver expression data from 31 mouse strains treated with vehicle or isoniazid for 3 days
Organism Mus musculus
Experiment type Expression profiling by array
Summary Isoniazid induced varying degrees of hepatic steatosis in an inbred strain Mouse Diversity Panel (MDP) study. RNA was isolated from all animals for analysis of gene expression changes in the liver. The objective of this study was to identify gene expression changes that drive isoniazid-induced steatosis.
 
Overall design 235 total samples from 31 strains were analyzed: N=4 per treatment and strain, except isoniazid-treated LP/J (N=3), PL/J (N=3), SM/J (N=2), NON/LtJ (N=3), LG/J (N=3), MA/MyJ (N=2), RIIIS/J (N=3), SEA/GnJ (N=2), and A/J (N=2) animals where animals that died before the completion of the study were excluded from data analysis; 13 of 31 strains exhibited findings of isoniazid-induced steatosis and were coded as responders.
 
Contributor(s) Mosedale M, Adkins K
Citation(s) 24848797
Submission date Mar 02, 2014
Last update date Feb 11, 2019
Contact name Merrie Mosedale
Organization name UNC Eshelman School of Pharmacy
Department Division of Pharmacotherapy and Experimental Therapeutics
Lab Institute for Drug Safety Sciences
Street address 301 Pharmacy Lane, Kerr Hall CB#7569
City Chapel Hill
State/province North Carolina
ZIP/Postal code 27599
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (235)
GSM1337844 BALB/cJ mouse liver, control animal 1
GSM1337845 BALB/cJ mouse liver, control animal 2
GSM1337846 BALB/cJ mouse liver, control animal 3
Relations
BioProject PRJNA239764

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE55489_RAW.tar 743.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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