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Series GSE54592 Query DataSets for GSE54592
Status Public on Mar 21, 2016
Title ER ChIP-seq of Androstenedione treated Letrozole Resistant Breast Cancer Cell line
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Acquired resistance to aromatase inhibitor (AI) therapy is a major clinical problem in the treatment of breast cancer. The detailed mechanisms of how tumour cells develop this resistance remain unclear. Here estrogen receptor ChIPseq analysis identifies adaptations of the ER in response to prolonged letrozole treatment.
Overall design Let-R cells were treated with either Androstenedione or vehicle and immunoprecipitated with anti-ER
Contributor(s) Young L, Fagan A, McBryan J, Vareslija D
Citation(s) 26763249
Submission date Jan 31, 2014
Last update date May 15, 2019
Contact name Leonie Young
Organization name Royal College of Surgeons, Ireland
Department Surgery
Lab Endocrine Oncology Research Group
Street address York Street
City Dublin
ZIP/Postal code Dublin 2
Country Ireland
Platforms (3)
GPL9115 Illumina Genome Analyzer II (Homo sapiens)
GPL10999 Illumina Genome Analyzer IIx (Homo sapiens)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (8)
GSM1319623 ER_LET-R_Andro_01
GSM1319624 ER_LET-R_Andro_02
GSM1319625 ER_LET-R_Veh_01
BioProject PRJNA237102
SRA SRP036128

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54592_AndroOnly_subtractVeh.bed.gz 1.2 Kb (ftp)(http) BED
GSE54592_AndroVeh_Overlap.bed.gz 1.1 Kb (ftp)(http) BED
GSE54592_RAW.tar 1.3 Gb (http)(custom) TAR (of BEDGRAPH)
GSE54592_VehOnly_subtractAndro.bed.gz 3.7 Kb (ftp)(http) BED
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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