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Series GSE53809 Query DataSets for GSE53809
Status Public on Jan 04, 2014
Title PGC7 and TET3 ChIP-seq results
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary PGC7 is a primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. TET3 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization.
 
Overall design PGC7 participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC by TET3 oxidization subsequent DNA demethylation. Thus we tested the co-localization of PGC7 and TET3 in specific loci by ChIP-seq assays.
 
Contributor(s) Bian C, Yu X
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jan 03, 2014
Last update date May 15, 2019
Contact name Xiaochun Yu
E-mail(s) xyu@coh.org
Organization name city of hope
Department Internal Medicine
Lab Dr. Xiaochun Yu
Street address 1500 E. Duarte Rd, Rm 202, Lippman-Graff Bldg
City Duarte
State/province CA
ZIP/Postal code 91010
Country USA
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (2)
GSM1301133 PGC7 ChIP-seq result
GSM1301134 TET3 ChIP-seq result
Relations
BioProject PRJNA233405
SRA SRP034919

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE53809_RAW.tar 544.1 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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