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Series GSE5296 Query DataSets for GSE5296
Status Public on Jul 12, 2006
Title Spinal Cord Injury Murine Model
Organism Mus musculus
Experiment type Expression profiling by array
Summary Traumatic spinal cord injury (SCI) initiates a complex series of pathophysiological secondary responses that lead to tissue loss and functional deficits.This study represents a comprehensive database of temporal changes in gene expression that underlie the secondary injury response that occurs in a well-defined mouse model of contusion injury.
Keywords: Time-Series
 
Overall design Global changes in gene expression that contribute to secondary injury in a C57BL6 mouse model of contusion injury were evaluated using Affymetrix Mouse Genome 430 2.0 arrays.Mice were subjected to a moderate injury at the T8 spinal segment under isoflurane anesthesia.Sections of cord (0.4 cm in length) were analyzed from the site of impact and from the immediately adjacent rostral and caudal regions at 0.5, 4, 24, 72 h and 7 and 28 days after injury (n=3/per group), sham-injury (n=2 per group), or from naïve mice (n=2). Four mice were pooled for each individual n, for a total of 12 mice for each injury time point.
 
Contributor(s) Faden A
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Submission date Jul 12, 2006
Last update date Feb 11, 2019
Contact name Eric Hoffman
E-mail ehoffman@cnmcresearch.org
Phone 202-884-6011
Fax 202-884-6014
URL http://pepr.cnmcresearch.org
Organization name Children's National Medical Center
Department Children's Research Institute
Lab Research Center for Genetic Medicine
Street address 111 Michigan Ave. 5th Floor
City Washington
State/province DC
ZIP/Postal code 20010
Country USA
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (96)
GSM118664 SCIM-A_I_0.5h-1MP
GSM118672 SCIM-A_I_0.5h-2MP
GSM119764 SCIM-A_I_0.5h-3MP
Relations
BioProject PRJNA96419

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE5296_RAW.tar 588.5 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file

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