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| Status |
Public on Nov 15, 2013 |
| Title |
Kidney from controls and SDHD-ESR mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hypoxia-inducible factor 1alpha (Hif1alpha) at normal oxygen tension, a theory referred to as pseudo-hypoxic drive. Other molecular processes, such as oxidative stress, apoptosis or chromatin remodeling have been also proposed to play a causative role. Nevertheless, the actual contribution of each of these mechanisms has not been definitively established. Moreover, the biological factors that determine the tissue-specificity of these tumors have not been identified. In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans.
We performed microarray analysis of kidney in order to identify other early gene expression changes elicited by SdhD deletion.
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| Overall design |
8 samples from heterozygous (+/-) and 8 samples from null mutants (SDHD-ESR), paired by two and hybrydized against a pool of 8 samples from homozygous wt (+/+) animals.
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| Contributor(s) |
Piruat JI |
| Citation(s) |
24465590 |
| |
| Submission date |
Nov 07, 2013 |
| Last update date |
Jan 19, 2018 |
| Contact name |
Jose I Piruat |
| E-mail(s) |
jpiruat-ibis@us.es
|
| Phone |
+34 955923088
|
| Organization name |
Institute of Biomedicine of Seville (IBIS)
|
| Department |
Hematology
|
| Lab |
202
|
| Street address |
Hospital Virgen del Rocio-Edif IBiS. Av. Manuel Siurot sn
|
| City |
Seville |
| ZIP/Postal code |
41013 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL10333 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version) |
|
| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE52197 |
Gene expression in adrenal medulla and kidney of a conditional mutant mouse in the SdhD gene |
|
| Relations |
| BioProject |
PRJNA227144 |
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