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Series GSE52123 Query DataSets for GSE52123
Status Public on Aug 13, 2014
Title Reinstatement of developmental stage-specific GATA4 enhancers controls the gene expression program in heart disease
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Summary Through integration of GATA4 genome-wide occupancy and RNA-seq dataset in embryonic conditional knockout heart, we identified a class of the master cardiac regulator GATA4 bound enhancers. With combinatorial assembly of chromatin signatures, we further refined that a unique type of fetal distal GATA4 enhancers enriched for H3K27ac, H3K4me1, but not for H3K4me3 and RNA polymerase II, are reinstated in adult hypertrophic heart.
 
Overall design Study Gata4 and histone modifications in E12.5, Adult, Banding and Sham, and to correlate to gene expression and heart function
 
Contributor(s) He A, Gu F, Hu Y, Ma Q, Ye L, Visel A, Pennacchio LA, Pu WT
Citation(s) 25249388
Submission date Nov 06, 2013
Last update date Mar 17, 2019
Contact name Fei Gu
E-mail alickgf@hotmail.com
Organization name Childrens hospital boston, Harvard Medical School
Department Cardiology
Lab William Pu
Street address 320 Longwood Ave.
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (45)
GSM1260008 Adult_Gata4_Ab_rep1
GSM1260009 Adult_Gata4_Ab_rep2
GSM1260010 Adult_Gata4_fb_rep1
Relations
BioProject PRJNA226752
SRA SRP032656

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52123_RAW.tar 8.1 Gb (http)(custom) TAR (of BW, TXT)
Raw data are available in SRA
Processed data provided as supplementary file

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