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Series GSE51704 Query DataSets for GSE51704
Status Public on Sep 05, 2014
Title Gene expression profiling of KLF5, GATA4 and GATA6 knock down in YCC3/AGS/KATOIII cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Three transcription factors KLF5, GATA4 and GATA6 are recurrently amplified in multiple gastric cancer cohorts, representing one type of lineage-survival oncogenes in gastric cancer. ChIP-Seq analysis of these three factors in multiple cell lines revealed that significant number of genomic sites are co-occupied by KLF5 and GATA4 and/or GATA6. Integrative analysis of ChIP-Seq and gene expression identified several targets of the three transcription factors in both cell lines and primary tumors, including HNF4A. These results suggest that KLF5, GATA4 and GATA6 interact and co-operate to regulate HNF4A and other genes to promote tumorigenesis in gastric cancer.
Overall design Gene expression profiling of KLF5, GATA4 and GATA6 knock down in YCC3/AGS/KATOIII cells
Contributor(s) Deng N, Chia N, Tan P
Citation(s) 25053715
Submission date Oct 25, 2013
Last update date Mar 25, 2019
Contact name Niantao Deng
Organization name Duke NUS Graduate Medical School
Street address Center for Computational Biology, level 6, 8 College Road
City Singapore
State/province Singapore
ZIP/Postal code 169857
Country Singapore
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (36)
GSM1250854 NT_siRNA_AGS_1
GSM1250855 NT_siRNA_AGS_2
GSM1250856 NT_siRNA_AGS_3
This SubSeries is part of SuperSeries:
GSE51706 Integrative study of cooperative lineage-survival oncogenes in gastric cancer
BioProject PRJNA224586

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE51704_RAW.tar 169.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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